STAY ALERT CHEWING GUM – ARCTIC MINT OR CINNAMON (10 PACKS, 5 PCS/PACK)

“The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers”

 

STUDY PERFORMED BY :

 

– Walter Reed Army Institute of Research, Department of Neurobiology and Behavior

– Pharmacokinetics – Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy,  University of Maryland at Baltimore.

  

“In summary, caffeine administered in the chewing gum formulation was absorbed at a significantly faster rate while its bioavailability was near comparable to that of the capsule formulation for the 100mg and 200mg dose groups.”

 

“Consequently, Stay Alert chewing gum is a convenient and effective means of rapidly administering caffeine and may prove useful in ameliorating the effects of mental or physical fatigue associated with sleep deprivation or shift work.”

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STUDY :

 

“Caffeine Maintains Vigilance and Marksmanship in Simulated Urban Operations with Sleep Deprivation”

   

STUDY PERFORMED BY :

     

– Walter Reed Army Institute of Research, Department of Neurobiology and Behavior
– Defense Research and Development Canada – Toronto

         

“Current military doctrine requires the ability to maintain round the clock operations in order to achieve mission objectives.  Sleep loss impairs cognitive performance, and physical tasks that involve self-pacing and motivation are also affected.”

                     

“Results: Caffeine maintained marksmanship vigilance in conventional troops at 85% for the duration of the second night without sleep as compared with the soldiers receiving the Placebo, who significantly declined to 61.4 + 28.2%.”

                  

“Conclusions: It was concluded that caffeine was an effective strategy to sustain vigilance and alertness during military operations involving sleep deprivation.”

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STUDY :

     

“Caffeine for the Sustainment of Mental Task Performance:  Formulations for Military Operations”

    

STUDY PERFORMED BY :

    

– Institute of Medicine , Committee on Military Nutrition Research, Food and Nutrition Board

 

“The use of a caffeinated chewing gum would appear to provide the most rapid absorption.”

    

“Chewing gums are more appropriate if rapid absorption and actions are needed, or weight or bulk is a concern.”

     

“Pills and gums are both very lightweight and small in size, so they can easily be carried in pockets; gum has the advantage of stimulating salivation and enhancing the speed of absorption.”

    

“The committee concludes that under certain circumstances, chewing gums may offer practical operational advantages over a food bar.”

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STUDY :

  

“Multiple Dose Pharmacokinetics of Caffeine Administered in Chewing Gum to Normal Healthy Volunteers”

   

STUDY PERFORMED BY :

  

– Walter Reed Army Institute of Research, Department of Neurobiology and Behavior

– Pharmacokinetics-Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School  of Pharmacy, University of Maryland at Baltimore.

    

“Subjects were randomly assigned to receive either a placebo, 50, 100 or 200mg of Caffeine (three doses at 2 hr intervals) as Stay Alert chewing gum.”

    

“Cognitive performance deficits resulting from sleep loss or fatigue could be more quickly reversed by caffeine administered in achieving gum formulations and maintained over a long period of time.”

        

“Absorption in a gum formulation occurs primarily through the buccal mucosa, a well accepted method of increasing the rate of drug absorption.  (Shargel et al., 1999)”

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STUDY :

   

“Efficacy of Multiple Caffeine Doses for Maintenance of Vigilance During Early Morning Operations”

    

STUDY PERFORMED BY :

     

– Walter Reed Army Institute of Research, Department of Behavioral Biology

      

“At 0300, 0500, and 0700 hrs subjects chewed two sticks of gum (Stay Alert chewing gum) containing caffeine (50, 100, or 200 mg) or placebo.”

             

“Conclusion:  These results indicate that bi-hourly administrations of caffeine 200 maintain vigilance performance across a single night without sleep.”